{"id":215363,"date":"2025-06-04T13:08:04","date_gmt":"2025-06-04T18:08:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/06\/crispr-gene-editing-in-blood-stem-cells-linked-to-premature-aging-effects-study-offers-solutions"},"modified":"2025-06-04T13:08:04","modified_gmt":"2025-06-04T18:08:04","slug":"crispr-gene-editing-in-blood-stem-cells-linked-to-premature-aging-effects-study-offers-solutions","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/06\/crispr-gene-editing-in-blood-stem-cells-linked-to-premature-aging-effects-study-offers-solutions","title":{"rendered":"CRISPR gene editing in blood stem cells linked to premature aging effects: Study offers solutions"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crispr-gene-editing-in-blood-stem-cells-linked-to-premature-aging-effects-study-offers-solutions.jpg\"><\/a><\/p>\n<p>Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system.<\/p>\n<p>The study, <a href=\"https:\/\/www.cell.com\/cell-reports-medicine\/fulltext\/S2666-3791(25)00230-7\" target=\"_blank\">published<\/a> in <i>Cell Reports Medicine<\/i>, outlines new strategies to overcome this hurdle, improving both the safety and efficacy of <a href=\"https:\/\/medicalxpress.com\/tags\/gene+editing\/\" rel=\"tag\" class=\"\">gene-editing<\/a>-based therapies for inherited blood disorders.<\/p>\n<p>The research was led by Dr. Raffaella Di Micco, group leader at SR-Tiget, New York Stem Cell Foundation Robertson Investigator and Associate Professor at the School for Advanced Studies (IUSS) of Pavia, in collaboration with Professor Luigi Naldini, Director of SR-Tiget, and several European research partners.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses in blood stem cells, compromising their long-term ability to regenerate the blood system. The study, published in Cell Reports Medicine, outlines new strategies to overcome [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412,269],"tags":[],"class_list":["post-215363","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215363"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215363\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}