{"id":215069,"date":"2025-05-30T10:07:48","date_gmt":"2025-05-30T15:07:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/how-the-fight-or-flight-response-resets-on-a-molecular-level"},"modified":"2025-05-30T10:07:48","modified_gmt":"2025-05-30T15:07:48","slug":"how-the-fight-or-flight-response-resets-on-a-molecular-level","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/how-the-fight-or-flight-response-resets-on-a-molecular-level","title":{"rendered":"How the fight-or-flight response resets on a molecular level"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-the-fight-or-flight-response-resets-on-a-molecular-level3.jpg\"><\/a><\/p>\n<p>Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this \u201cfight-or-flight\u201d or stress response is a molecular cycle that results in the activation of protein kinase A (PKA), a protein involved in everything from metabolism to memory formation. Now, a study by researchers at Penn State has revealed how this cycle resets between stressful events, so the body is prepared to take on new challenges.<\/p>\n<p>The details of this reset mechanism, uncovered through a combination of imaging, structural and biochemical techniques, are <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c16269\" target=\"_blank\">published<\/a> in the Journal of the American Chemical Society.<\/p>\n<p>\u201cSome of the early changes in the fight-or-flight response include the release of hormones, like adrenaline from stress or glucagon from starvation,\u201d said Ganesh Anand, associate professor of chemistry and of biochemistry and <a href=\"https:\/\/phys.org\/tags\/molecular+biology\/\" rel=\"tag\" class=\"\">molecular biology<\/a> in the Penn State Eberly College of Science and lead author of the paper.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this \u201cfight-or-flight\u201d or stress response is a molecular cycle that results in the activation of protein kinase A (PKA), a protein involved [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,19],"tags":[],"class_list":["post-215069","post","type-post","status-publish","format-standard","hentry","category-biological","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=215069"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/215069\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=215069"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=215069"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=215069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}