{"id":214992,"date":"2025-05-29T09:09:04","date_gmt":"2025-05-29T14:09:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/blood-brain-barrier-guardian-shows-promise-against-alzheimers"},"modified":"2025-05-29T09:09:04","modified_gmt":"2025-05-29T14:09:04","slug":"blood-brain-barrier-guardian-shows-promise-against-alzheimers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/blood-brain-barrier-guardian-shows-promise-against-alzheimers","title":{"rendered":"Blood-Brain Barrier \u2018Guardian\u2019 Shows Promise Against Alzheimer\u2019s"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/blood-brain-barrier-guardian-shows-promise-against-alzheimers.jpg\"><\/a><\/p>\n<p>A new drug targeting inflammation in the brain has been shown to bolster the blood-brain barrier in mice, pioneering a potential shift in the fight against neurodegenerative diseases like <a href=\"https:\/\/www.sciencealert.com\/go\/IaO\" class=\"\" rel=\"nofollow\" target=\"_self\">Alzheimer\u2019s<\/a>.<\/p>\n<p>\u201cFinding [the drug] blocks brain inflammation and protects the blood-brain barrier was an exciting new discovery,\u201d <a href=\"https:\/\/thedaily.case.edu\/potential-new-treatment-for-alzheimers-disease-other-neurodegenerative-conditions\/\">says<\/a> pathologist Sanford Markowitz from Case Western Reserve University (CWRU).<\/p>\n<p>What\u2019s more, the researchers note that amyloid levels \u2013 the <a href=\"https:\/\/www.sciencealert.com\/newly-identified-proteins-may-explain-devastating-effects-of-alzheimers\">abnormally clumping proteins<\/a> traditionally thought to play a role in the progress of Alzheimer\u2019s \u2013 remained the same. This suggests the new treatment, focusing on an immune protein called 15-PGDH, targets a completely different physiological pathway than many existing medications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new drug targeting inflammation in the brain has been shown to bolster the blood-brain barrier in mice, pioneering a potential shift in the fight against neurodegenerative diseases like Alzheimer\u2019s. \u201cFinding [the drug] blocks brain inflammation and protects the blood-brain barrier was an exciting new discovery,\u201d says pathologist Sanford Markowitz from Case Western Reserve University [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-214992","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=214992"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214992\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=214992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=214992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=214992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}