{"id":214714,"date":"2025-05-25T05:04:23","date_gmt":"2025-05-25T10:04:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/candidate-drug-that-boosts-protective-brain-protein-in-mice-has-potential-to-treat-alzheimers-disease"},"modified":"2025-05-25T05:04:23","modified_gmt":"2025-05-25T10:04:23","slug":"candidate-drug-that-boosts-protective-brain-protein-in-mice-has-potential-to-treat-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/candidate-drug-that-boosts-protective-brain-protein-in-mice-has-potential-to-treat-alzheimers-disease","title":{"rendered":"Candidate drug that boosts protective brain protein in mice has potential to treat Alzheimer\u2019s disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/candidate-drug-that-boosts-protective-brain-protein-in-mice-has-potential-to-treat-alzheimers-disease.jpg\"><\/a><\/p>\n<p>As researchers work to improve treatment of Alzheimer\u2019s disease, new research by UCLA Health identified a candidate drug that reduces levels of a toxic form of a protein in the brain caused by the disease and improved memory in mice by boosting production of a protective protein.<\/p>\n<p>In a <a href=\"https:\/\/www.nature.com\/articles\/s44386-025-00009-2\" target=\"_blank\">study<\/a> published in <i><i>npj Drug Discovery<\/i>,<\/i> UCLA Health researchers targeted the protein clusterin (CLU), which is crucial in preventing the build-up of amyloid-beta plaques and tau proteins that disrupt communication between <a href=\"https:\/\/medicalxpress.com\/tags\/brain+cells\/\" rel=\"tag\" class=\"\">brain cells<\/a> and lead to memory impairment\u2014a hallmark symptom of Alzheimer\u2019s disease.<\/p>\n<p>More than a decade ago, a variant of the gene that encodes clusterin was identified as the third strongest genetic risk factor for late-onset Alzheimer\u2019s disease. It was recently reported that increased CLU protein could provide protection against Alzheimer\u2019s disease and <a href=\"https:\/\/medicalxpress.com\/tags\/cognitive+decline\/\" rel=\"tag\" class=\"\">cognitive decline<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>As researchers work to improve treatment of Alzheimer\u2019s disease, new research by UCLA Health identified a candidate drug that reduces levels of a toxic form of a protein in the brain caused by the disease and improved memory in mice by boosting production of a protective protein. In a study published in npj Drug Discovery, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495,47],"tags":[],"class_list":["post-214714","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=214714"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214714\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=214714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=214714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=214714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}