{"id":214613,"date":"2025-05-23T18:28:19","date_gmt":"2025-05-23T23:28:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/pi3k-akt-signaling-mediates-stress-inducible-amyloid-formation-through-c-myc"},"modified":"2025-05-23T18:28:19","modified_gmt":"2025-05-23T23:28:19","slug":"pi3k-akt-signaling-mediates-stress-inducible-amyloid-formation-through-c-myc","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/pi3k-akt-signaling-mediates-stress-inducible-amyloid-formation-through-c-myc","title":{"rendered":"PI3K\/AKT signaling mediates stress-inducible amyloid formation through c-Myc"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pi3k-akt-signaling-mediates-stress-inducible-amyloid-formation-through-c-myc2.jpg\"><\/a><\/p>\n<p>Lacroix et al. demonstrate that heat-induced activation of the PI3K\/AKT signaling cascade drives the formation of functional amyloid aggregates that protect cells from harsh environmental conditions. Here, activation of PI3K and AKT represses GSK3-mediated degradation of c-Myc, leading to upregulation of nucleating noncoding RNAs that mediate this physiological amyloidogenic event.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lacroix et al. demonstrate that heat-induced activation of the PI3K\/AKT signaling cascade drives the formation of functional amyloid aggregates that protect cells from harsh environmental conditions. Here, activation of PI3K and AKT represses GSK3-mediated degradation of c-Myc, leading to upregulation of nucleating noncoding RNAs that mediate this physiological amyloidogenic event.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-214613","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=214613"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214613\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=214613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=214613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=214613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}