{"id":214175,"date":"2025-05-17T05:18:09","date_gmt":"2025-05-17T10:18:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/chronic-pain-and-mental-well-being-linked-to-ibs-risk-genetic-study-identifies-modifiable-factors"},"modified":"2025-05-17T05:18:09","modified_gmt":"2025-05-17T10:18:09","slug":"chronic-pain-and-mental-well-being-linked-to-ibs-risk-genetic-study-identifies-modifiable-factors","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/chronic-pain-and-mental-well-being-linked-to-ibs-risk-genetic-study-identifies-modifiable-factors","title":{"rendered":"Chronic pain and mental well-being linked to IBS risk: Genetic study identifies modifiable factors"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/chronic-pain-and-mental-well-being-linked-to-ibs-risk-genetic-study-identifies-modifiable-factors.jpg\"><\/a><\/p>\n<p>Irritable bowel syndrome (IBS) is a prevalent and debilitating gastrointestinal disorder affecting approximately 5%\u201310% of the global population. Characterized by abdominal pain, bloating, and altered bowel habits, IBS imposes a significant burden on quality of life and health care systems worldwide.<\/p>\n<p>Despite its prevalence, the exact pathogenesis of IBS remains elusive, and effective prevention strategies are lacking. Di Liu and colleagues conducted a comprehensive Mendelian randomization (MR) study\u2014an approach that uses genetic variants as instrumental variables to infer causality.<\/p>\n<p>The study integrates Mendelian randomization (MR) and multiresponse MR (MR2) analyses to distinguish genuine causal relationships from shared or spurious associations. The research is <a href=\"http:\/\/egastroenterology.bmj.com\/lookup\/doi\/10.1136\/egastro-2024-100126\" target=\"_blank\">published<\/a> in the journal eGastroenterology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Irritable bowel syndrome (IBS) is a prevalent and debilitating gastrointestinal disorder affecting approximately 5%\u201310% of the global population. Characterized by abdominal pain, bloating, and altered bowel habits, IBS imposes a significant burden on quality of life and health care systems worldwide. Despite its prevalence, the exact pathogenesis of IBS remains elusive, and effective prevention strategies [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412,1495,47],"tags":[],"class_list":["post-214175","post","type-post","status-publish","format-standard","hentry","category-genetics","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=214175"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214175\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=214175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=214175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=214175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}