{"id":214133,"date":"2025-05-16T05:20:17","date_gmt":"2025-05-16T10:20:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/advanced-gene-editor-enables-more-precise-insertion-of-complete-genes"},"modified":"2025-05-16T05:20:17","modified_gmt":"2025-05-16T10:20:17","slug":"advanced-gene-editor-enables-more-precise-insertion-of-complete-genes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/advanced-gene-editor-enables-more-precise-insertion-of-complete-genes","title":{"rendered":"Advanced gene editor enables more precise insertion of complete genes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/advanced-gene-editor-enables-more-precise-insertion-of-complete-genes2.jpg\"><\/a><\/p>\n<p>Ask scientists which gene-editing tool is most needed to advance gene therapy, and they\u2019d probably describe a system that\u2019s now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard.<\/p>\n<p>The gene editor\u2014called evoCAST\u2014goes a long way toward solving a problem that has confounded the development of gene therapies from the field\u2019s beginnings: How to add long stretches of DNA to defined locations in the <a href=\"https:\/\/phys.org\/tags\/human+genome\/\" rel=\"tag\" class=\"\">human genome<\/a> without creating unwanted modifications.<\/p>\n<p>The latest iteration of the editor, which utilizes complex enzymes found in bacteria, can be programmed to insert an entire gene\u2014or multiple genes\u2014into a specific location in the human genome with an efficiency suitable for gene therapy. Details of the editor are described in a <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adt5199\" target=\"_blank\">paper<\/a> published in Science.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ask scientists which gene-editing tool is most needed to advance gene therapy, and they\u2019d probably describe a system that\u2019s now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard. The gene editor\u2014called evoCAST\u2014goes a long [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-214133","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=214133"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/214133\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=214133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=214133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=214133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}