{"id":213318,"date":"2025-05-06T02:09:29","date_gmt":"2025-05-06T07:09:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/one-protein-mitigates-huntingtons-disease-and-one-exacerbates-it"},"modified":"2025-05-06T02:09:29","modified_gmt":"2025-05-06T07:09:29","slug":"one-protein-mitigates-huntingtons-disease-and-one-exacerbates-it","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/one-protein-mitigates-huntingtons-disease-and-one-exacerbates-it","title":{"rendered":"One protein mitigates Huntington\u2019s disease, and one exacerbates it"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/one-protein-mitigates-huntingtons-disease-and-one-exacerbates-it2.jpg\"><\/a><\/p>\n<p>A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington\u2019s disease?<\/p>\n<p>They found that HTT is something like a traffic controller inside neurons, moving different cargo along neuronal highways called axons in concert with other proteins that are key for cellular function and survival. Reduce the amount of non-mutant HTT and you\u2019ll create the neurological equivalent of traffic jams and roadblocks.<\/p>\n<p>Now, the researchers have learned more about what can control the traffic-controlling HTT.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington\u2019s disease? They found that HTT is something like a traffic controller inside neurons, moving different cargo along neuronal highways called axons in concert with other proteins that are key for [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-213318","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/213318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=213318"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/213318\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=213318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=213318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=213318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}