{"id":213267,"date":"2025-05-05T05:06:54","date_gmt":"2025-05-05T10:06:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/single-cell-rna-sequencing-reveals-heterogeneity-in-fibrotic-scars-after-spinal-cord-injury"},"modified":"2025-05-05T05:06:54","modified_gmt":"2025-05-05T10:06:54","slug":"single-cell-rna-sequencing-reveals-heterogeneity-in-fibrotic-scars-after-spinal-cord-injury","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/single-cell-rna-sequencing-reveals-heterogeneity-in-fibrotic-scars-after-spinal-cord-injury","title":{"rendered":"Single-cell RNA sequencing reveals heterogeneity in fibrotic scars after spinal cord injury"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/single-cell-rna-sequencing-reveals-heterogeneity-in-fibrotic-scars-after-spinal-cord-injury.jpg\"><\/a><\/p>\n<p>Myofibroblasts generate fibrotic scars after spinal cord injury (SCI). This is typically regarded as an impediment to nerve regeneration. Understanding the heterogeneous characteristics of \ufb01brotic scars might help to develop strategies for remodeling \ufb01brotic scars after SCI. However, the composition, origin and function of fibrotic scars have been a subject of ongoing debate in the field.<\/p>\n<p>A recent study led by Profs. Dai Jianwu and Zhao Yannan from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences employed a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq) to demonstrate the heterogeneous distribution, source, and function of meningeal fibroblasts and perivascular fibroblasts in fibrotic scars.<\/p>\n<p>Their research is <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-50564-x\" target=\"_blank\">published<\/a> in the journal Nature Communications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Myofibroblasts generate fibrotic scars after spinal cord injury (SCI). This is typically regarded as an impediment to nerve regeneration. Understanding the heterogeneous characteristics of \ufb01brotic scars might help to develop strategies for remodeling \ufb01brotic scars after SCI. However, the composition, origin and function of fibrotic scars have been a subject of ongoing debate in the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,412],"tags":[],"class_list":["post-213267","post","type-post","status-publish","format-standard","hentry","category-biological","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/213267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=213267"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/213267\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=213267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=213267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=213267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}