{"id":213070,"date":"2025-05-02T09:12:11","date_gmt":"2025-05-02T14:12:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/lysosome-destabilization-found-to-drive-iron-dependent-cell-death-in-cancer"},"modified":"2025-05-02T09:12:11","modified_gmt":"2025-05-02T14:12:11","slug":"lysosome-destabilization-found-to-drive-iron-dependent-cell-death-in-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/lysosome-destabilization-found-to-drive-iron-dependent-cell-death-in-cancer","title":{"rendered":"Lysosome destabilization found to drive iron-dependent cell death in cancer"},"content":{"rendered":"

<\/a><\/p>\n

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed cell death, is also necessary for the proper development and function of the body. It has also been a focus of researchers developing treatments for cancer by finding ways to activate the cell death of cancer cells themselves.<\/p>\n

Ferroptosis is a recently discovered form of programmed cell death<\/a> and has been a promising target for the development of cancer treatments. It is mediated by iron molecules, with the cell dying through the degradation of the phospholipid bilayer by oxidation, a process called lipid peroxidation<\/a>. However, recent studies have shown that certain cancer cells are less susceptible to ferroptosis, raising concerns that this resistance could pose a barrier to future therapeutics.<\/p>\n

In a paper published in Nature Communications<\/i><\/a>, researchers from Kyushu University, using cultured cells and mice, found that the lipid peroxidation of the lysosomes\u2014the organelle responsible for degrading and recycling molecules in a cell\u2014plays a critical role in the execution of ferroptosis.<\/p>\n","protected":false},"excerpt":{"rendered":"

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed cell death, is also necessary for the proper development and function of the body. It has also been a focus of researchers developing treatments for cancer [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-213070","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/213070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=213070"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/213070\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=213070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=213070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=213070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}