{"id":212963,"date":"2025-05-01T05:25:33","date_gmt":"2025-05-01T10:25:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/05\/discovery-of-histidine-adp-ribose-molecule-reveals-new-bacterial-immune-strategy"},"modified":"2025-05-01T05:25:33","modified_gmt":"2025-05-01T10:25:33","slug":"discovery-of-histidine-adp-ribose-molecule-reveals-new-bacterial-immune-strategy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/05\/discovery-of-histidine-adp-ribose-molecule-reveals-new-bacterial-immune-strategy","title":{"rendered":"Discovery of histidine-ADP-ribose molecule reveals new bacterial immune strategy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/discovery-of-histidine-adp-ribose-molecule-reveals-new-bacterial-immune-strategy2.jpg\"><\/a><\/p>\n<p>A research team has uncovered a previously unknown type of immune signaling molecule\u2014a novel compound combining histidine and ADP-ribose\u2014produced by bacteria\u2019s Thoeris II defense system in response to viral infection. This finding expands our understanding of bacterial immunity and may pave the way for innovative tools in biotechnology, gene editing, and antimicrobial therapy.<\/p>\n<p>The paper, titled \u201cTIR domains produce histidine-ADPR as an immune signal in bacteria,\u201d is <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-08930-2\" target=\"_blank\">published<\/a> in the journal <i>Nature<\/i>, and the team includes scientists at Vilnius University\u2019s Life Sciences Centre (VU LSC), together with colleagues from the Weizmann Institute of Science (Israel) and Harvard Medical School.<\/p>\n<p>The discovery sheds light on how bacteria, much like humans, communicate viral threats at the molecular level\u2014in this case, triggering a self-sacrificing response to halt virus spread and protect bacterial populations. Beyond its fundamental significance, the finding opens exciting avenues for rethinking immune mechanisms and virus-host interactions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team has uncovered a previously unknown type of immune signaling molecule\u2014a novel compound combining histidine and ADP-ribose\u2014produced by bacteria\u2019s Thoeris II defense system in response to viral infection. This finding expands our understanding of bacterial immunity and may pave the way for innovative tools in biotechnology, gene editing, and antimicrobial therapy. The paper, [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11],"tags":[],"class_list":["post-212963","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=212963"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212963\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=212963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=212963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=212963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}