{"id":212879,"date":"2025-04-30T14:12:28","date_gmt":"2025-04-30T19:12:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/divergent-actions-of-physiological-and-pathological-amyloid-%ce%b2-on-synapses-in-live-human-brain-slice-cultures"},"modified":"2025-04-30T14:12:28","modified_gmt":"2025-04-30T19:12:28","slug":"divergent-actions-of-physiological-and-pathological-amyloid-%ce%b2-on-synapses-in-live-human-brain-slice-cultures","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/divergent-actions-of-physiological-and-pathological-amyloid-%ce%b2-on-synapses-in-live-human-brain-slice-cultures","title":{"rendered":"Divergent actions of physiological and pathological amyloid-\u03b2 on synapses in live human brain slice cultures"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/divergent-actions-of-physiological-and-pathological-amyloid-ceb2-on-synapses-in-live-human-brain-slice-cultures.jpg\"><\/a><\/p>\n<p>Understanding synapse loss in Alzheimer\u2019s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological A\u03b2 has differing effects on synapses in live human brain slice cultures.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Understanding synapse loss in Alzheimer\u2019s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological A\u03b2 has differing effects on synapses in live human brain slice cultures.<\/p>\n","protected":false},"author":701,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-212879","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/701"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=212879"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212879\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=212879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=212879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=212879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}