{"id":212750,"date":"2025-04-29T13:06:06","date_gmt":"2025-04-29T18:06:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/computational-analysis-clarifies-cancer-risk-for-families-with-genetic-variants"},"modified":"2025-04-29T13:06:06","modified_gmt":"2025-04-29T18:06:06","slug":"computational-analysis-clarifies-cancer-risk-for-families-with-genetic-variants","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/computational-analysis-clarifies-cancer-risk-for-families-with-genetic-variants","title":{"rendered":"Computational analysis clarifies cancer risk for families with genetic variants"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/computational-analysis-clarifies-cancer-risk-for-families-with-genetic-variants2.jpg\"><\/a><\/p>\n<p>QIMR Berghofer-led research has shown that new advanced computational prediction tools can improve the accuracy of genetic testing for families affected by an inherited condition that significantly increases their risk of developing cancer, paving the way to better targeted care.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.ajhg.2025.01.012\" target=\"_blank\">The findings<\/a> have been published in the <i>American Journal of Human Genetics<\/i> alongside complementary studies by international collaborators, which together show how incorporating the new computational biology tools with existing modeling methods improved the predictive power of genetic test results.<\/p>\n<p>Computational tools are used to predict if and how a genetic <a href=\"https:\/\/medicalxpress.com\/tags\/variant\/\" rel=\"tag\" class=\"\">variant<\/a> is likely to impact the function of the protein encoded by the gene.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>QIMR Berghofer-led research has shown that new advanced computational prediction tools can improve the accuracy of genetic testing for families affected by an inherited condition that significantly increases their risk of developing cancer, paving the way to better targeted care. The findings have been published in the American Journal of Human Genetics alongside complementary studies [\u2026]<\/p>\n","protected":false},"author":732,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,412],"tags":[],"class_list":["post-212750","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/732"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=212750"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212750\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=212750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=212750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=212750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}