{"id":212708,"date":"2025-04-29T02:08:39","date_gmt":"2025-04-29T07:08:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/tumor-derived-erythropoietin-acts-as-an-immunosuppressive-switch-in-cancer-immunity"},"modified":"2025-04-29T02:08:39","modified_gmt":"2025-04-29T07:08:39","slug":"tumor-derived-erythropoietin-acts-as-an-immunosuppressive-switch-in-cancer-immunity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/tumor-derived-erythropoietin-acts-as-an-immunosuppressive-switch-in-cancer-immunity","title":{"rendered":"Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tumor-derived-erythropoietin-acts-as-an-immunosuppressive-switch-in-cancer-immunity2.jpg\"><\/a><\/p>\n<p>A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system\u2019s response to cancer.<\/p>\n<p>Blocking the activity of the protein turns formerly \u201ccold,\u201d or immune-resistant, liver tumors in mice into \u201chot\u201d tumors teeming with cancer-fighting immune cells. When combined with an immunotherapy that further activates these immune cells against the cancer, the treatment led to complete regression of existing liver tumors in most mice. Treated animals lived for the duration of the experiment. In contrast, control animals survived only a few weeks.<\/p>\n<p>\u201cThis is a fundamental breakthrough in our understanding of how the immune system is turned off and on in cancer,\u201d said the senior author published the work in <i>Science<\/i>. \u201cI could not be more excited about this discovery, and I hope treatments that target the mechanism we uncovered will quickly move forward to human trials.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system\u2019s response to cancer. Blocking the activity of the protein turns formerly \u201ccold,\u201d or immune-resistant, liver tumors in mice into \u201chot\u201d tumors teeming with cancer-fighting immune cells. When [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-212708","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=212708"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212708\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=212708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=212708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=212708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}