{"id":212165,"date":"2025-04-23T01:28:50","date_gmt":"2025-04-23T06:28:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/dna-repair-mechanism-may-hold-key-to-overcoming-tumor-resistance-to-radiotherapy"},"modified":"2025-04-23T01:28:50","modified_gmt":"2025-04-23T06:28:50","slug":"dna-repair-mechanism-may-hold-key-to-overcoming-tumor-resistance-to-radiotherapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/dna-repair-mechanism-may-hold-key-to-overcoming-tumor-resistance-to-radiotherapy","title":{"rendered":"DNA repair mechanism may hold key to overcoming tumor resistance to radiotherapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dna-repair-mechanism-may-hold-key-to-overcoming-tumor-resistance-to-radiotherapy2.jpg\"><\/a><\/p>\n<p>A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes.<\/p>\n<p>The result was <a href=\"https:\/\/www.nature.com\/articles\/s41418-025-01472-0\" target=\"_blank\">published<\/a> in <i>Cell Death &amp; Differentiation<\/i>. The team was led by Professor Zhao Guoping at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.<\/p>\n<p>The efficacy of radiotherapy is largely limited by the DNA damage repair capacity of tumor cells. When ionizing radiation induces DNA double-strand breaks\u2014the primary lethal damage\u2014tumor cells often exhibit abnormal overexpression of DNA repair proteins, establishing a robust damage response system that drives clinical radioresistance. To address this challenge, the team deciphered the regulatory network of epigenetic modifications in DNA damage repair.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death &amp; Differentiation. The team was led by Professor Zhao Guoping at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences. The efficacy of [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-212165","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=212165"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212165\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=212165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=212165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=212165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}