{"id":212040,"date":"2025-04-22T01:06:22","date_gmt":"2025-04-22T06:06:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/light-activated-probe-reveals-how-tuberculosis-evades-immune-defenses"},"modified":"2025-04-22T01:06:22","modified_gmt":"2025-04-22T06:06:22","slug":"light-activated-probe-reveals-how-tuberculosis-evades-immune-defenses","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/light-activated-probe-reveals-how-tuberculosis-evades-immune-defenses","title":{"rendered":"Light-activated probe reveals how tuberculosis evades immune defenses"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/light-activated-probe-reveals-how-tuberculosis-evades-immune-defenses2.jpg\"><\/a><\/p>\n<p>Tuberculosis (TB) is an infectious disease that kills more than a million people worldwide every year. The pathogen that causes the disease, Mycobacterium tuberculosis, is deadly in part because of its complex outer envelope, which helps it evade immune responses of infected hosts.<\/p>\n<p>In an <i>ACS Infectious Diseases<\/i> <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.5c00068\" target=\"_blank\">paper<\/a>, researchers developed a chemical probe to study a key component of this envelope. Their results provide a step toward finding new ways of inactivating the bacterium.<\/p>\n<p>Because curing TB requires taking drugs for months, which can result in TB resistance to some antibiotics, scientists are working to develop new treatments. One possible target is the bacterium\u2019s outermost layer, called the mycomembrane, which protects the bacteria from stressors. When M. <a href=\"https:\/\/medicalxpress.com\/tags\/tuberculosis\/\" rel=\"tag\" class=\"\">tuberculosis<\/a> is attacked by a host\u2019s macrophage <a href=\"https:\/\/medicalxpress.com\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a>, the mycomembrane produces compounds that suppress the infected host\u2019s immune response.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tuberculosis (TB) is an infectious disease that kills more than a million people worldwide every year. The pathogen that causes the disease, Mycobacterium tuberculosis, is deadly in part because of its complex outer envelope, which helps it evade immune responses of infected hosts. In an ACS Infectious Diseases paper, researchers developed a chemical probe to [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-212040","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=212040"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/212040\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=212040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=212040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=212040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}