{"id":211730,"date":"2025-04-18T02:15:40","date_gmt":"2025-04-18T07:15:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/study-identifies-link-between-body-clock-disruption-and-metabolic-disease"},"modified":"2025-04-18T02:15:40","modified_gmt":"2025-04-18T07:15:40","slug":"study-identifies-link-between-body-clock-disruption-and-metabolic-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/study-identifies-link-between-body-clock-disruption-and-metabolic-disease","title":{"rendered":"Study identifies link between body clock disruption and metabolic disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-identifies-link-between-body-clock-disruption-and-metabolic-disease.jpg\"><\/a><\/p>\n<p>Northwestern Medicine investigators have discovered how disruptions in the circadian rhythm in our muscles combined with poor diet can contribute to the development of diabetes, according to a recent study <a href=\"https:\/\/pnas.org\/doi\/10.1073\/pnas.2424046122\" target=\"_blank\">published<\/a> in Proceedings of the National Academy of Sciences.<\/p>\n<p>\u201cWhen we mess up our <a href=\"https:\/\/medicalxpress.com\/tags\/circadian+rhythms\/\" rel=\"tag\" class=\"\">circadian rhythms<\/a> through environmental circadian disruption like <a href=\"https:\/\/medicalxpress.com\/tags\/shift+work\/\" rel=\"tag\" class=\"\">shift work<\/a>, jet lag or <a href=\"https:\/\/medicalxpress.com\/tags\/sleep+deprivation\/\" rel=\"tag\" class=\"\">sleep deprivation<\/a>, it\u2019s possible that it\u2019s impacting our muscle clocks and metabolism. If that\u2019s happening and we are combining this with an unhealthy diet, this might make it more likely for us to develop glucose intolerance and diabetes,\u201d said Clara Peek, Ph.D., assistant professor of Biochemistry and Molecular Genetics and of Medicine in the Division of Endocrinology, Metabolism and Molecular Medicine, who was senior author of the study.<\/p>\n<p>The body\u2019s natural <a href=\"https:\/\/medicalxpress.com\/tags\/circadian+clock\/\" rel=\"tag\" class=\"\">circadian clock<\/a> is comprised of proteins called <a href=\"https:\/\/medicalxpress.com\/tags\/transcription+factors\/\" rel=\"tag\" class=\"\">transcription factors<\/a> that are present throughout the body, including <a href=\"https:\/\/medicalxpress.com\/tags\/muscle+tissue\/\" rel=\"tag\" class=\"\">muscle tissue<\/a>. The clock synchronizes physical and behavioral changes to the external environment during the 24-hour light cycle.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Northwestern Medicine investigators have discovered how disruptions in the circadian rhythm in our muscles combined with poor diet can contribute to the development of diabetes, according to a recent study published in Proceedings of the National Academy of Sciences. \u201cWhen we mess up our circadian rhythms through environmental circadian disruption like shift work, jet lag [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-211730","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=211730"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211730\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=211730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=211730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=211730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}