{"id":211714,"date":"2025-04-17T17:11:06","date_gmt":"2025-04-17T22:11:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/time-machine-enzyme-could-improve-mrna-based-therapeutics"},"modified":"2025-04-17T17:11:06","modified_gmt":"2025-04-17T22:11:06","slug":"time-machine-enzyme-could-improve-mrna-based-therapeutics","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/time-machine-enzyme-could-improve-mrna-based-therapeutics","title":{"rendered":"\u2018Time machine\u2019 enzyme could improve mRNA-based therapeutics"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/time-machine-enzyme-could-improve-mrna-based-therapeutics2.jpg\"><\/a><\/p>\n<p>Researchers from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) have described a new mechanism that improves the efficiency of mRNA-based therapies. The research findings could facilitate the development of novel therapeutics against cancers and infectious diseases.<\/p>\n<p>The scientific experiments were carried out at IIMCB, but important contributions also came from collaborators at the Faculty of Physics and Faculty of Biology of the University of Warsaw, the Medical University of Warsaw, and the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences. The study by the Polish researchers has just been <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-08842-1\" target=\"_blank\">published<\/a> in Nature.<\/p>\n<p>\u201cmRNA vaccines played a key role in controlling the spread of the pandemic. However, mRNA itself is an exceptionally unstable molecule. This does not affect the safety of the therapy but limits its effectiveness\u2014for example, by shortening the duration of action. A particularly important role in mRNA stability is played by its so-called poly(A) <a href=\"https:\/\/phys.org\/tags\/tail\/\" rel=\"tag\" class=\"\">tail<\/a>. In our research, we examined these limitations,\u201d says Prof. Andrzej Dziembowski from the Laboratory of RNA Biology\u2014ERA Chairs Group at the International Institute of Molecular and Cell Biology in Warsaw, one of the lead authors of the study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) have described a new mechanism that improves the efficiency of mRNA-based therapies. The research findings could facilitate the development of novel therapeutics against cancers and infectious diseases. The scientific experiments were carried out at IIMCB, but important contributions also came from collaborators [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,11,219,1515],"tags":[],"class_list":["post-211714","post","type-post","status-publish","format-standard","hentry","category-biological","category-biotech-medical","category-physics","category-time-travel"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=211714"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211714\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=211714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=211714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=211714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}