{"id":211051,"date":"2025-04-10T06:13:39","date_gmt":"2025-04-10T11:13:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/scientists-propose-a-targeted-lysosomal-dysfunction-approach-for-glioblastoma-treatment"},"modified":"2025-04-10T06:13:39","modified_gmt":"2025-04-10T11:13:39","slug":"scientists-propose-a-targeted-lysosomal-dysfunction-approach-for-glioblastoma-treatment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/scientists-propose-a-targeted-lysosomal-dysfunction-approach-for-glioblastoma-treatment","title":{"rendered":"Scientists propose a targeted lysosomal dysfunction approach for glioblastoma treatment"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-propose-a-targeted-lysosomal-dysfunction-approach-for-glioblastoma-treatment2.jpg\"><\/a><\/p>\n<p>Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-56946-z\" target=\"_blank\">report<\/a> in <i>Nature Communications<\/i> on how the targeted suppression of lysosome function may lead to brain cancer therapy.<\/p>\n<p>Glioblastoma is a type of brain cancer with a very poor prognosis of survival. Causes of <a href=\"https:\/\/medicalxpress.com\/tags\/glioblastoma\/\" rel=\"tag\" class=\"\">glioblastoma<\/a> are not known, and there is no method for preventing the cancer. Traditional treatment includes the drug temozolomide (TMZ). In many cases, TMZ kills glioblastoma cells, but a significant portion of patients show resistance to the drug.<\/p>\n<p>Changes in the levels of metabolites\u2014<a href=\"https:\/\/medicalxpress.com\/tags\/small+molecules\/\" rel=\"tag\" class=\"\">small molecules<\/a> playing key roles in metabolic processes in living organisms\u2014have been observed in TMZ-resistant glioblastoma cells, pointing to the importance of understanding and targeting metabolic pathways in the context of cancer therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications on how the targeted suppression of lysosome function may lead to brain cancer therapy. Glioblastoma is a type of brain cancer with a very poor prognosis of survival. Causes of glioblastoma are not known, and there is no method for preventing the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-211051","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=211051"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211051\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=211051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=211051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=211051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}