{"id":211010,"date":"2025-04-09T21:10:39","date_gmt":"2025-04-10T02:10:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/smart-delivery-tech-boosts-crispr-efficiency-restores-vision-in-mice"},"modified":"2025-04-09T21:10:39","modified_gmt":"2025-04-10T02:10:39","slug":"smart-delivery-tech-boosts-crispr-efficiency-restores-vision-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/smart-delivery-tech-boosts-crispr-efficiency-restores-vision-in-mice","title":{"rendered":"Smart delivery tech boosts CRISPR efficiency, restores vision in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/smart-delivery-tech-boosts-crispr-efficiency-restores-vision-in-mice2.jpg\"><\/a><\/p>\n<p>A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR\/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes\u2014demonstrated successfully in living mouse models that are blind due to a mutation.<\/p>\n<p>This system also holds promise for advancing <a href=\"https:\/\/phys.org\/tags\/cancer+therapy\/\" rel=\"tag\" class=\"\">cancer therapy<\/a> by enabling precise genetic manipulation of engineered <a href=\"https:\/\/phys.org\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a>, making them more universally compatible and thus more accessible for a larger group of cancer patients.<\/p>\n<p>The work is <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867425002880\" target=\"_blank\">published<\/a> in the journal <i>Cell<\/i>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR\/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes\u2014demonstrated successfully in living mouse models [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-211010","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=211010"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/211010\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=211010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=211010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=211010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}