{"id":210985,"date":"2025-04-09T13:24:33","date_gmt":"2025-04-09T18:24:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/a-cloaked-human-stem-derived-neural-graft-capable-of-functional-integration-and-immune-evasion-in-rodent-models"},"modified":"2025-04-09T13:24:33","modified_gmt":"2025-04-09T18:24:33","slug":"a-cloaked-human-stem-derived-neural-graft-capable-of-functional-integration-and-immune-evasion-in-rodent-models","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/a-cloaked-human-stem-derived-neural-graft-capable-of-functional-integration-and-immune-evasion-in-rodent-models","title":{"rendered":"A cloaked human stem-derived neural graft capable of functional integration and immune evasion in rodent models"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-cloaked-human-stem-derived-neural-graft-capable-of-functional-integration-and-immune-evasion-in-rodent-models2.jpg\"><\/a><\/p>\n<p>Immune evasion of human stem-cell-derived neural graft in rodent models.<\/p>\n<p>Transplantation rejection is the main challenge in human pluripotent stem cell (hPSC)-derived therapies.<\/p>\n<p>The researchers used hPSC line (termed H1-FS-8IM), engineered to overexpress 8 immunomodulatory transgenes, to enable transplant immune evasion.<\/p>\n<p>They show in co-cultures, H1-FS-8IM PSC-derived midbrain neurons evaded rejection by T lymphocytes, natural killer cells, macrophages, and dendritic cells.<\/p>\n<p>The authors also provide preclinical evidence of pluripotent stem cell line evading immune detection after neural engraftment in a humanized immune system mouse model and reversal of motor symptoms in Parkinsonian rats.<\/p>\n<p>Incorporation of a suicide gene within the universal donor cell ensures safety for cell-based therapies. <a href=\"https:\/\/sciencemission.com\/A-cloaked-human-stem-cell-derived-neural-graft\">https:\/\/sciencemission.com\/A-cloaked-human-stem-cell-derived-neural-graft<\/a><\/p>\n<hr>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/04\/a-cloaked-human-stem-derived-neural-graft-capable-of-functional-integration-and-immune-evasion-in-rodent-models\">Continue reading \u201cA cloaked human stem-derived neural graft capable of functional integration and immune evasion in rodent models\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Immune evasion of human stem-cell-derived neural graft in rodent models. Transplantation rejection is the main challenge in human pluripotent stem cell (hPSC)-derived therapies. The researchers used hPSC line (termed H1-FS-8IM), engineered to overexpress 8 immunomodulatory transgenes, to enable transplant immune evasion. They show in co-cultures, H1-FS-8IM PSC-derived midbrain neurons evaded rejection by T lymphocytes, natural [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-210985","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210985"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210985\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}