{"id":210957,"date":"2025-04-09T09:12:49","date_gmt":"2025-04-09T14:12:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/human-mini-brains-reveal-protein-gramd1bs-potential-role-in-neurodegeneration"},"modified":"2025-04-09T09:12:49","modified_gmt":"2025-04-09T14:12:49","slug":"human-mini-brains-reveal-protein-gramd1bs-potential-role-in-neurodegeneration","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/human-mini-brains-reveal-protein-gramd1bs-potential-role-in-neurodegeneration","title":{"rendered":"Human \u2018mini-brains\u2019 reveal protein GRAMD1B\u2019s potential role in neurodegeneration"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/human-mini-brains-reveal-protein-gramd1bs-potential-role-in-neurodegeneration.jpg\"><\/a><\/p>\n<p>Researchers at The Ohio State University Wexner Medical Center and College of Medicine have discovered a new way that neurons act in neurodegeneration by using human neural organoids\u2014also known as \u201cmini-brain\u201d models\u2014from patients with frontotemporal lobar degeneration (FTLD).<\/p>\n<p>Understanding this new pathway could help researchers find better treatments for FTLD and Alzheimer\u2019s, the two most common forms of dementia that lead to <a href=\"https:\/\/medicalxpress.com\/tags\/cognitive+decline\/\" rel=\"tag\" class=\"\">cognitive decline<\/a>.<\/p>\n<p>Researchers used advanced techniques to study <a href=\"https:\/\/medicalxpress.com\/tags\/neurons\/\" rel=\"tag\" class=\"\">neurons<\/a> from patients and mice, including growing human neural organoids (mini-brains) that can feature several cell types found in the brain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at The Ohio State University Wexner Medical Center and College of Medicine have discovered a new way that neurons act in neurodegeneration by using human neural organoids\u2014also known as \u201cmini-brain\u201d models\u2014from patients with frontotemporal lobar degeneration (FTLD). Understanding this new pathway could help researchers find better treatments for FTLD and Alzheimer\u2019s, the two most [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-210957","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210957"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210957\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}