{"id":210818,"date":"2025-04-07T18:18:52","date_gmt":"2025-04-07T23:18:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/abstract-understanding-the-pathogenesis-of-nup98-fusion-mediated-leukemia"},"modified":"2025-04-07T18:18:52","modified_gmt":"2025-04-07T23:18:52","slug":"abstract-understanding-the-pathogenesis-of-nup98-fusion-mediated-leukemia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/abstract-understanding-the-pathogenesis-of-nup98-fusion-mediated-leukemia","title":{"rendered":"Abstract: Understanding the pathogenesis of NUP98-fusion mediated leukemia\u2014"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract4.jpg\"><\/a><\/p>\n<p>Suming Huang &amp; team show the <i><i>HoxBlin <\/i>c<\/i> long non-coding RNA serves as an oncogenic regulator that controls 3D nuclear organization, chromatin accessibility and gene transcription related to leukemogenesis.<\/p>\n<p>The figure shows H&amp;E staining of sternum and spleen from WT and B-ALL <i><i>HoxBlin <\/i>c<\/i> Tg mice.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.<\/p>\n<p><sup>2<\/sup>Department of Molecular Medicine, University of Texas Health <i>Science<\/i> Center at San Antonio, San Antonio, Texas, USA.<\/p>\n<p><sup>3<\/sup>Genetics Branch, Center for <i>Cancer Res<\/i>earch, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Suming Huang &amp; team show the HoxBlin c long non-coding RNA serves as an oncogenic regulator that controls 3D nuclear organization, chromatin accessibility and gene transcription related to leukemogenesis. The figure shows H&amp;E staining of sternum and spleen from WT and B-ALL HoxBlin c Tg mice. 1Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Pennsylvania State [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-210818","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210818"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210818\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210818"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}