{"id":210675,"date":"2025-04-06T01:12:06","date_gmt":"2025-04-06T06:12:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/pax-translocations-remodel-mitochondrial-metabolism-through-altered-leucine-usage-in-rhabdomyosarcoma"},"modified":"2025-04-06T01:12:06","modified_gmt":"2025-04-06T06:12:06","slug":"pax-translocations-remodel-mitochondrial-metabolism-through-altered-leucine-usage-in-rhabdomyosarcoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/pax-translocations-remodel-mitochondrial-metabolism-through-altered-leucine-usage-in-rhabdomyosarcoma","title":{"rendered":"PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pax-translocations-remodel-mitochondrial-metabolism-through-altered-leucine-usage-in-rhabdomyosarcoma2.jpg\"><\/a><\/p>\n<p>Now online!By using an engineered human-iPSC-derived muscle progenitor model, it is shown that PAX fusion transcription factors remodel 3D chromatin maps and transcriptional circuits to activate oncogenes and drive mitochondrial OXPHOS in high-risk rhabdomyosarcoma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online!By using an engineered human-iPSC-derived muscle progenitor model, it is shown that PAX fusion transcription factors remodel 3D chromatin maps and transcriptional circuits to activate oncogenes and drive mitochondrial OXPHOS in high-risk rhabdomyosarcoma.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-210675","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210675"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210675\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}