{"id":210620,"date":"2025-04-05T06:14:35","date_gmt":"2025-04-05T11:14:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/the-local-microenvironment-suppresses-the-synergy-between-irradiation-and-anti-pd1-therapy-in-breast-to-brain-metastasis"},"modified":"2025-04-05T06:14:35","modified_gmt":"2025-04-05T11:14:35","slug":"the-local-microenvironment-suppresses-the-synergy-between-irradiation-and-anti-pd1-therapy-in-breast-to-brain-metastasis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/the-local-microenvironment-suppresses-the-synergy-between-irradiation-and-anti-pd1-therapy-in-breast-to-brain-metastasis","title":{"rendered":"The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-local-microenvironment-suppresses-the-synergy-between-irradiation-and-anti-pd1-therapy-in-breast-to-brain-metastasis2.jpg\"><\/a><\/p>\n<p>Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages drive this suppression, limiting the efficacy of combined irradiation and anti-PD1 therapy, highlighting potential therapeutic targets for brain metastases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages drive this suppression, limiting the efficacy of combined irradiation and anti-PD1 therapy, highlighting potential therapeutic targets for brain metastases.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-210620","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210620"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210620\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}