{"id":210576,"date":"2025-04-04T17:05:54","date_gmt":"2025-04-04T22:05:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/nad-controls-circadian-reprogramming-through-per2-nuclear-translocation-to-counter-aging"},"modified":"2025-04-04T17:05:54","modified_gmt":"2025-04-04T22:05:54","slug":"nad-controls-circadian-reprogramming-through-per2-nuclear-translocation-to-counter-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/nad-controls-circadian-reprogramming-through-per2-nuclear-translocation-to-counter-aging","title":{"rendered":"NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nad-controls-circadian-reprogramming-through-per2-nuclear-translocation-to-counter-aging2.jpg\"><\/a><\/p>\n<p>Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD<sup>+<\/sup>, yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here, we reveal that supplementation with the NAD <sup>+<\/sup> precursor nicotinamide riboside (NR) markedly reprograms metabolic and stress-response pathways that decline with aging through inhibition of the clock repressor PER2. NR enhances BMAL1 chromatin binding genome-wide through PER2 <sup>K680<\/sup> deacetylation, which in turn primes PER2 phosphorylation within a domain that controls nuclear transport and stability and that is mutated in human advanced sleep phase syndrome.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD+, yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here, we reveal that supplementation with the NAD + precursor nicotinamide riboside (NR) markedly reprograms metabolic and stress-response pathways that decline [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-210576","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210576"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210576\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}