{"id":210390,"date":"2025-04-02T13:11:24","date_gmt":"2025-04-02T18:11:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/ucla-team-developing-inhalable-gene-editing-treatment-for-cf"},"modified":"2025-04-02T13:11:24","modified_gmt":"2025-04-02T18:11:24","slug":"ucla-team-developing-inhalable-gene-editing-treatment-for-cf","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/ucla-team-developing-inhalable-gene-editing-treatment-for-cf","title":{"rendered":"UCLA team developing inhalable gene-editing treatment for CF"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ucla-team-developing-inhalable-gene-editing-treatment-for-cf2.jpg\"><\/a><\/p>\n<p>Researchers at the University of California, Los Angeles (UCLA) are developing a gene-editing therapy \u2014 designed to be delivered as a one-time inhalable treatment \u2014 that aims to correct the underlying mutations that cause <a href=\"https:\/\/cysticfibrosisnewstoday.com\/cystic-fibrosis-overview\/\">cystic fibrosis<\/a> (CF).<\/p>\n<p>The team is using tiny fat-based particles to deliver the gene-editing machinery to lung stem cells, where, they believe, gene correction could be permanent. The treatment, according to a <a href=\"https:\/\/www.universityofcalifornia.edu\/news\/breathing-new-life-working-toward-inhalable-gene-therapy-cystic-fibrosis\">university news story<\/a>, could offer hope to people with the genetic disease who do not benefit from <a href=\"https:\/\/cysticfibrosisnewstoday.com\/approved-treatments-for-cystic-fibrosis\/\">current therapies<\/a>.<\/p>\n<p><a href=\"https:\/\/cysticfibrosisnewstoday.com\/cystic-fibrosis-causes\/\">CF is caused<\/a> by mutations in the <em>CFTR<\/em> gene, which normally produces a protein of the same name. This CFTR protein helps regulate the flow of water and salt molecules in and out of certain cells, which is essential for the production of mucus. In CF, missing or dysfunctional CFTR instead results in the accumulation of thick and sticky mucus in several organs, particularly the lungs. This, in turn, leads to <a href=\"https:\/\/cysticfibrosisnewstoday.com\/symptoms-of-cystic-fibrosis\/\">symptoms<\/a> like shortness of breath, cough, and frequent lung infections.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of California, Los Angeles (UCLA) are developing a gene-editing therapy \u2014 designed to be delivered as a one-time inhalable treatment \u2014 that aims to correct the underlying mutations that cause cystic fibrosis (CF). The team is using tiny fat-based particles to deliver the gene-editing machinery to lung stem cells, where, they [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-210390","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210390"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210390\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}