{"id":210347,"date":"2025-04-02T02:11:09","date_gmt":"2025-04-02T07:11:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/04\/nebulized-vasopressin-penetrates-csf-and-improves-social-cognition-without-inducing-aggression-in-a-rhesus-monkey-model-of-autism"},"modified":"2025-04-02T02:11:09","modified_gmt":"2025-04-02T07:11:09","slug":"nebulized-vasopressin-penetrates-csf-and-improves-social-cognition-without-inducing-aggression-in-a-rhesus-monkey-model-of-autism","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/04\/nebulized-vasopressin-penetrates-csf-and-improves-social-cognition-without-inducing-aggression-in-a-rhesus-monkey-model-of-autism","title":{"rendered":"Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nebulized-vasopressin-penetrates-csf-and-improves-social-cognition-without-inducing-aggression-in-a-rhesus-monkey-model-of-autism2.jpg\"><\/a><\/p>\n<p>I very much enjoyed reading this nicely done preclinical study on using nebulized vasopressin to improve social cognition in low-sociality rhesus monkeys. Reading about their study design in particular was highly informative\/educational! #preclinical #medicine #biomedicine<\/p>\n<hr>\n<p>Low cerebrospinal (CSF) arginine vasopressin (AVP) concentration is a biomarker of social impairment in low-social monkeys and children with autism, suggesting that AVP administration may improve primate social functioning. However, AVP administration also increases aggression, at least in \u201cneurotypical\u201d animals with intact AVP signaling. Here, we tested the effects of a voluntary drug administration method in low-social male rhesus monkeys with high autistic-like trait burden. Monkeys received nebulized AVP or placebo, using a within-subjects design. Study 1 (N = 8) investigated the effects of AVP administration on social cognition in two tests comparing responses to social <i>versus<\/i> nonsocial stimuli. Test 1: Placebo-administered monkeys lacked face recognition memory, whereas face recognition memory was \u201crescued\u201d following AVP administration.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I very much enjoyed reading this nicely done preclinical study on using nebulized vasopressin to improve social cognition in low-sociality rhesus monkeys. Reading about their study design in particular was highly informative\/educational! #preclinical #medicine #biomedicine Low cerebrospinal (CSF) arginine vasopressin (AVP) concentration is a biomarker of social impairment in low-social monkeys and children with autism, [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,32,47],"tags":[],"class_list":["post-210347","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-education","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=210347"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/210347\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=210347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=210347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=210347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}