{"id":209942,"date":"2025-03-28T10:10:59","date_gmt":"2025-03-28T15:10:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/dysregulation-of-%ce%b3%ce%b4-intraepithelial-lymphocytes-precedes-crohns-disease-like-ileitis"},"modified":"2025-03-28T10:10:59","modified_gmt":"2025-03-28T15:10:59","slug":"dysregulation-of-%ce%b3%ce%b4-intraepithelial-lymphocytes-precedes-crohns-disease-like-ileitis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/dysregulation-of-%ce%b3%ce%b4-intraepithelial-lymphocytes-precedes-crohns-disease-like-ileitis","title":{"rendered":"Dysregulation of \u03b3\u03b4 intraepithelial lymphocytes precedes Crohn\u2019s disease\u2013like ileitis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dysregulation-of-ceb3ceb4-intraepithelial-lymphocytes-precedes-crohns-disease-like-ileitis2.jpg\"><\/a><\/p>\n<p>A new <i><i>Science<\/i> Immunology<\/i> study shows that disruptions to immunosuppressive intraepithelial lymphocytes and intestinal immunity occurs prior to the onset of chronic ileal inflammation in mouse models of Crohn\u2019s Disease.<\/p>\n<hr>\n<p>Multiple layers of \u03b3\u03b4 IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new Science Immunology study shows that disruptions to immunosuppressive intraepithelial lymphocytes and intestinal immunity occurs prior to the onset of chronic ileal inflammation in mouse models of Crohn\u2019s Disease. Multiple layers of \u03b3\u03b4 IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-209942","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209942"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209942\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}