{"id":209428,"date":"2025-03-21T11:26:01","date_gmt":"2025-03-21T16:26:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/ligand-induced-ubiquitination-unleashes-lag3-immune-checkpoint-function-by-hindering-membrane-sequestration-of-signaling-motifs"},"modified":"2025-03-21T11:26:01","modified_gmt":"2025-03-21T16:26:01","slug":"ligand-induced-ubiquitination-unleashes-lag3-immune-checkpoint-function-by-hindering-membrane-sequestration-of-signaling-motifs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/ligand-induced-ubiquitination-unleashes-lag3-immune-checkpoint-function-by-hindering-membrane-sequestration-of-signaling-motifs","title":{"rendered":"Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ligand-induced-ubiquitination-unleashes-lag3-immune-checkpoint-function-by-hindering-membrane-sequestration-of-signaling-motifs2.jpg\"><\/a><\/p>\n<p>Now online!This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement and its regulation by non-degradative polyubiquitination within the tumor microenvironment. The findings highlight LAG3\/CBL coexpression as a promising biomarker for selecting suitable patients for LAG3-targeted immunotherapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online!This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement and its regulation by non-degradative polyubiquitination within the tumor microenvironment. The findings highlight LAG3\/CBL coexpression as a promising biomarker for selecting suitable patients for LAG3-targeted immunotherapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-209428","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209428"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209428\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}