{"id":209358,"date":"2025-03-21T02:29:53","date_gmt":"2025-03-21T07:29:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/batf2-is-a-regulator-of-interferon-%ce%b3-signaling-in-astrocytes-during-neuroinflammation"},"modified":"2025-03-21T02:29:53","modified_gmt":"2025-03-21T07:29:53","slug":"batf2-is-a-regulator-of-interferon-%ce%b3-signaling-in-astrocytes-during-neuroinflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/batf2-is-a-regulator-of-interferon-%ce%b3-signaling-in-astrocytes-during-neuroinflammation","title":{"rendered":"BATF2 is a regulator of interferon-\u03b3 signaling in astrocytes during neuroinflammation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/batf2-is-a-regulator-of-interferon-ceb3-signaling-in-astrocytes-during-neuroinflammation2.jpg\"><\/a><\/p>\n<p>Mechanism of neuroinflammation protection by astrocytes.<\/p>\n<p>How astrocytes controls neuroinflammation is not clearly understood.<\/p>\n<p>The researchers demonstrate that the upregulation of basic leucine zipper ATF-like transcription factor (BATF)2 downstream of IFNg regulates the inflammatory potential of astrocytes during neuroinflammation.<\/p>\n<p>In vivo evidence suggests that BATF2 limits CNS autoimmunity and the expression of IFNg-driven inflammatory mediators.<\/p>\n<p>Mechanistically, BATF2 binds and prevents the overexpression of IFN regulatory factor (IRF)1 and IRF1 targets such as caspase-1. Batf2\u2212\/\u2212 mice exhibit exacerbated clinical disease severity in a murine model of central nervous system autoimmunity and express increased astrocyte-specific IRF1 and caspase-1, suggesting an amplified IFN response in vivo.<\/p>\n<p>They also demonstrate that BATF2 expressed primarily in astrocytes within multiple sclerosis lesions and that this expression is colocalized with IRF1.<\/p>\n<p>These data suggest that BATF2 contributes to protective mechanisms in astrocytes during chronic neuroinflammation. <a href=\"https:\/\/sciencemission.com\/BATF2-and-neuroinflammation\">https:\/\/sciencemission.com\/BATF2-and-neuroinflammation<\/a><\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/03\/batf2-is-a-regulator-of-interferon-%ce%b3-signaling-in-astrocytes-during-neuroinflammation\">Continue reading \u201cBATF2 is a regulator of interferon-\u03b3 signaling in astrocytes during neuroinflammation\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Mechanism of neuroinflammation protection by astrocytes. How astrocytes controls neuroinflammation is not clearly understood. The researchers demonstrate that the upregulation of basic leucine zipper ATF-like transcription factor (BATF)2 downstream of IFNg regulates the inflammatory potential of astrocytes during neuroinflammation. In vivo evidence suggests that BATF2 limits CNS autoimmunity and the expression of IFNg-driven inflammatory mediators. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-209358","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209358"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209358\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}