{"id":209349,"date":"2025-03-21T02:26:06","date_gmt":"2025-03-21T07:26:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/inhibiting-bacterial-gene-translation-using-sirna"},"modified":"2025-03-21T02:26:06","modified_gmt":"2025-03-21T07:26:06","slug":"inhibiting-bacterial-gene-translation-using-sirna","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/inhibiting-bacterial-gene-translation-using-sirna","title":{"rendered":"Inhibiting bacterial gene translation using siRNA"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/inhibiting-bacterial-gene-translation-using-sirna2.jpg\"><\/a><\/p>\n<p>Protecting pneumococcal infection in elderly.<\/p>\n<p>The researchers. provide insights into mechanisms underlying respiratory bacterial susceptibility in the elderly.<\/p>\n<p>Circadian rhythms is impaired in the aging process. The authors wanted to figure out the relation ship between impaired circadian rhythm and bacterial infections during aging.<\/p>\n<p>They demonstrate that the altered circadian expression of the nuclear receptor Rev-erb-a and the apelin\/apelin receptor (APJ) in aged lungs associates with dysregulated time-of-day control of pulmonary immune defenses against pneumococcal infections.<\/p>\n<p>The authors found an interaction between Rev-erb-\u03b1 and the apelinergic axis that controls host defenses against S. <i>pneumoniae<\/i> via alveolar macrophages. Pharmacological repression of Rev-erb-\u03b1 in elderly mice resulted in greater resistance to pneumococcal infection. <a href=\"https:\/\/sciencemission.com\/pneumococcal-infection-in-elderly\">https:\/\/sciencemission.com\/pneumococcal-infection-in-elderly<\/a><\/p>\n<hr>\n<p>Silva Angulo et al. provide insights into mechanisms underlying respiratory bacterial susceptibility in the elderly. The authors demonstrate that the altered circadian expression of the nuclear receptor Rev-erb-\u03b1 and the apelin\/apelin receptor (APJ) in aged lungs associates with dysregulated time-of-day control of pulmonary immune defenses against pneumococcal infections.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/03\/inhibiting-bacterial-gene-translation-using-sirna\">Continue reading \u201cInhibiting bacterial gene translation using siRNA\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Protecting pneumococcal infection in elderly. The researchers. provide insights into mechanisms underlying respiratory bacterial susceptibility in the elderly. Circadian rhythms is impaired in the aging process. The authors wanted to figure out the relation ship between impaired circadian rhythm and bacterial infections during aging. They demonstrate that the altered circadian expression of the nuclear receptor [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-209349","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209349"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209349\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}