{"id":209327,"date":"2025-03-20T20:11:52","date_gmt":"2025-03-21T01:11:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/klotho-gene-therapy-increases-lifespan"},"modified":"2025-03-20T20:11:52","modified_gmt":"2025-03-21T01:11:52","slug":"klotho-gene-therapy-increases-lifespan","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/klotho-gene-therapy-increases-lifespan","title":{"rendered":"Klotho Gene Therapy Increases Lifespan"},"content":{"rendered":"<p><\/p>\n<p><iframe loading=\"lazy\" title=\"Longevity Snapshot 8  - Klotho Gene Therapy Increases Lifespan\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/H7EcNmliEXM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>\u201c.<\/p>\n<hr>\n<p>Gene therapy was used to increase levels of Klotho, one of the first longevity genes discovered in the 1990\u2019s, in mice. This led to improved physical fitness, muscular regenerative capacity, bone micrstructure, neurogenesis and a 20% increase in lifespan.<\/p>\n<p>Contents:<\/p>\n<p>Intro 0:00<br \/> Figure 1 \u2014 Longevity experiment follow-up and AAV treatment effectivity assessment 1:20<br \/> Figure 2 \u2014 Physical tests and histological analysis of muscular tissue from treated naturally aged animals 4:04<br \/> Figure 3 \u2014 Histological analysis of muscle from s-KL-treated animals 7 days after transplantation 6:27<br \/> Figure 4 \u2014 MicroCT structural and gene expression analysis in treated bones of 24-MO mice 7:34<br \/> Figure 5 \u2014 Histological analysis of Iba1, GFAP, and neurogenesis markers in CNS from aged animals 8:52<br \/> Figure 6 \u2014 Transcriptomic analysis of hippocampal RNA-seq data 9:59<br \/> Graphical Abstract &amp; Conclusion 11:04.<\/p>\n<p>Study reviewed:<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/03\/klotho-gene-therapy-increases-lifespan\">Continue reading \u201cKlotho Gene Therapy Increases Lifespan\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201c. Gene therapy was used to increase levels of Klotho, one of the first longevity genes discovered in the 1990\u2019s, in mice. This led to improved physical fitness, muscular regenerative capacity, bone micrstructure, neurogenesis and a 20% increase in lifespan. Contents: Intro 0:00 Figure 1 \u2014 Longevity experiment follow-up and AAV treatment effectivity assessment 1:20 [\u2026]<\/p>\n","protected":false},"author":731,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-209327","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/731"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209327"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209327\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}