{"id":209144,"date":"2025-03-19T15:02:21","date_gmt":"2025-03-19T20:02:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/mutated-dna-restored-to-normal-in-gene-therapy-advance"},"modified":"2025-03-19T15:02:21","modified_gmt":"2025-03-19T20:02:21","slug":"mutated-dna-restored-to-normal-in-gene-therapy-advance","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/mutated-dna-restored-to-normal-in-gene-therapy-advance","title":{"rendered":"Mutated DNA Restored to Normal in Gene Therapy Advance"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mutated-dna-restored-to-normal-in-gene-therapy-advance.jpg\"><\/a><\/p>\n<p>Researchers have corrected a disease-causing gene mutation with a single infusion carrying a treatment that precisely targeted the errant gene.<\/p>\n<p>This was the first time a mutated gene has been restored to normal.<\/p>\n<p>The small study of nine patients announced Monday by the company Beam Therapeutics of Cambridge, Mass., involved fixing a spelling error involving the four base sequences \u2014 G, A, C and T \u2014 in DNA. The effect was to change an incorrect DNA letter to the right one. The result was a normal gene that functioned as it should, potentially halting liver and lung damage of patients with a rare disorder.<\/p>\n<hr>\n<p>The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have corrected a disease-causing gene mutation with a single infusion carrying a treatment that precisely targeted the errant gene. This was the first time a mutated gene has been restored to normal. The small study of nine patients announced Monday by the company Beam Therapeutics of Cambridge, Mass., involved fixing a spelling error involving [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-209144","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209144"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209144\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}