{"id":209110,"date":"2025-03-19T04:12:11","date_gmt":"2025-03-19T09:12:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/qrich1-mediates-an-intracellular-checkpoint-for-cd8-t-cell-activation-via-the-card11-signalosome"},"modified":"2025-03-19T04:12:11","modified_gmt":"2025-03-19T09:12:11","slug":"qrich1-mediates-an-intracellular-checkpoint-for-cd8-t-cell-activation-via-the-card11-signalosome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/qrich1-mediates-an-intracellular-checkpoint-for-cd8-t-cell-activation-via-the-card11-signalosome","title":{"rendered":"QRICH1 mediates an intracellular checkpoint for CD8+ T cell activation via the CARD11 signalosome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/qrich1-mediates-an-intracellular-checkpoint-for-cd8-t-cell-activation-via-the-card11-signalosome2.jpg\"><\/a><\/p>\n<p>Scientists demonstrate that the protein QRICH1 limits T cell activation by inhibiting <i>CARD11<\/i> signaling to NFkB after T cell receptor stimulation.<\/p>\n<p>Read more in <i><i>Science<\/i> Immunology<\/i>.<\/p>\n<hr>\n<p>QRICH1 negatively regulates CD8+ T cell activation by fine-tuning <i>CARD11<\/i> signaling to NF-\u03baB.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists demonstrate that the protein QRICH1 limits T cell activation by inhibiting CARD11 signaling to NFkB after T cell receptor stimulation. Read more in Science Immunology. QRICH1 negatively regulates CD8+ T cell activation by fine-tuning CARD11 signaling to NF-\u03baB.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-209110","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209110"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209110\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}