{"id":209094,"date":"2025-03-19T00:11:59","date_gmt":"2025-03-19T05:11:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/triggering-cancer-cells-to-self-destruct-could-help-tumors-to-shrink"},"modified":"2025-03-19T00:11:59","modified_gmt":"2025-03-19T05:11:59","slug":"triggering-cancer-cells-to-self-destruct-could-help-tumors-to-shrink","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/triggering-cancer-cells-to-self-destruct-could-help-tumors-to-shrink","title":{"rendered":"Triggering Cancer Cells To Self-Destruct Could Help Tumors to Shrink"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/triggering-cancer-cells-to-self-destruct-could-help-tumors-to-shrink.jpg\"><\/a><\/p>\n<p>Cells function through an intricate network of proteins, each designed for specific tasks like metabolism, tissue repair, and immune defense. These proteins are built using genetic blueprints in our DNA. A process called alternative splicing enables a single gene to generate multiple mRNA transcripts \u2014 molecules carrying genetic instructions \u2014 allowing for protein diversity.<\/p>\n<p>In healthy cells, this process maintains balance. Cancer cells, however, disrupt that process to fuel their unchecked growth by disabling proteins that regulate cell proliferation.<\/p>\n<p>The researchers focused on a genetic element known as a poison exon. This natural \u201coff switch\u201d prevents the production of certain proteins by marking their RNA messages for destruction before they can be translated. Cancer cells suppress the poison exon in a key gene called TRA2\u03b2. Without this regulation, TRA2\u03b2 levels rise, promoting tumor growth and making cancer cells more aggressive.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cells function through an intricate network of proteins, each designed for specific tasks like metabolism, tissue repair, and immune defense. These proteins are built using genetic blueprints in our DNA. A process called alternative splicing enables a single gene to generate multiple mRNA transcripts \u2014 molecules carrying genetic instructions \u2014 allowing for protein diversity. In [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-209094","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=209094"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/209094\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=209094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=209094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=209094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}