{"id":208975,"date":"2025-03-17T22:29:40","date_gmt":"2025-03-18T03:29:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/mechanisms-of-chronic-postsurgical-pain"},"modified":"2025-03-17T22:29:40","modified_gmt":"2025-03-18T03:29:40","slug":"mechanisms-of-chronic-postsurgical-pain","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/mechanisms-of-chronic-postsurgical-pain","title":{"rendered":"Mechanisms of chronic postsurgical pain"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mechanisms-of-chronic-postsurgical-pain.jpg\"><\/a><\/p>\n<p>Central sensitization: analysis by physio meets science.<\/p>\n<p>Neurophysiological Mechanism of Central Sensitization in the Spinal Cord following Surgery:<\/p>\n<p>\u25b6\ufe0f Central sensitization was first described by Woolf in 1983 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6656869\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/6656869\/<\/a>) as a form of long-term adaptive neuroplasticity that amplifies the transmission of nociceptive information by affecting spinal cord neurons and is believed to be a principal neurophysiological mechanism with regard to pain persistence.<\/p>\n<p>\u25b6\ufe0f Peripheral nociception can trigger a prolonged increase in the excitability of dorsal root ganglia (DRG) neurons, which transmit nociceptive signals to the spinal cord, resulting in central sensitization.<\/p>\n<p>\u25b6\ufe0f This condition involves heightened responsiveness of spinal neurons, driven by signaling molecules like adenosine triphosphate (ATP) and neurotransmitters such as glutamate (Glu) and substance P (SP).<\/p>\n<p>\u25b6\ufe0f These molecules activate specific receptors on spinal neurons, including purinergic receptor 2 (P2-R), N-methyl-D-aspartate receptor (NMDAR), \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), and neurokinin 1 receptor (NK1R).<\/p>\n<p>\u25b6\ufe0f The activation of these receptors sets off a cascade of intracellular pathways involving enzymes like calcium\/calmodulin-dependent protein kinase II (CaMKII), protein kinase C (PKC), protein kinase A (PKA), mechanistic target of rapamycin (mTOR), phosphoinositide 3-kinase (PI3K), and extracellular signal-regulated kinases 1\/2 (ERK1\/2), all of which amplify the transmission of nociceptive signals to the brain.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/03\/mechanisms-of-chronic-postsurgical-pain\">Continue reading \u201cMechanisms of chronic postsurgical pain\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Central sensitization: analysis by physio meets science. Neurophysiological Mechanism of Central Sensitization in the Spinal Cord following Surgery: \u25b6\ufe0f Central sensitization was first described by Woolf in 1983 (https:\/\/pubmed.ncbi.nlm.nih.gov\/6656869\/) as a form of long-term adaptive neuroplasticity that amplifies the transmission of nociceptive information by affecting spinal cord neurons and is believed to be a principal [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495,47],"tags":[],"class_list":["post-208975","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=208975"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208975\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=208975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=208975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=208975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}