{"id":208665,"date":"2025-03-14T04:16:27","date_gmt":"2025-03-14T09:16:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/bridging-the-gaps-between-jcv-infection-models-and-human-disease"},"modified":"2025-03-14T04:16:27","modified_gmt":"2025-03-14T09:16:27","slug":"bridging-the-gaps-between-jcv-infection-models-and-human-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/bridging-the-gaps-between-jcv-infection-models-and-human-disease","title":{"rendered":"Bridging the gaps between JCV infection models and human disease"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/bridging-the-gaps-between-jcv-infection-models-and-human-disease.jpg\"><\/a><\/p>\n<p>Glial replication and proliferation support JC virus demyelination.<\/p>\n<p>In HIV infected patients, JC virus (JCV) can cause a devastating demyelinating disease of the CNS known as progressive multifocal leukoencephalopathy (PML).<\/p>\n<p>JCV replicates in human glial progenitor cells and astrocytes, which undergo viral T-antigen-triggered mitosis, enabling viral replication.<\/p>\n<p>The authors were able to demonstrate that dividing human astrocytes supported JCV propagation to a substantially greater degree than did mitotically quiescent cells.<\/p>\n<p>They also show that JCV infection greatly accentuated by cuprizone-induced demyelination and its associated mobilization of glial progenitor cells and triggered the death of both uninfected and infected glia, reflecting significant bystander death. <a href=\"https:\/\/sciencemission.com\/JCV-infection-models\">https:\/\/sciencemission.com\/JCV-infection-models<\/a><\/p>\n<hr>\n<p>\n<strong>This scientific commentary refers to \u2018JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation\u2019 by Li <em>et al<\/em>. (<a class=\"\" href=\"https:\/\/doi.org\/10.1093\/brain\/awae252\" target=\"_blank\" data-google-interstitial=\"false\"><a href=\"https:\/\/doi.org\/10.1093\/brain\/awae252\">https:\/\/doi.org\/10.1093\/brain\/awae252<\/a><\/a>).<\/strong><\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/03\/bridging-the-gaps-between-jcv-infection-models-and-human-disease\">Continue reading \u201cBridging the gaps between JCV infection models and human disease\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glial replication and proliferation support JC virus demyelination. In HIV infected patients, JC virus (JCV) can cause a devastating demyelinating disease of the CNS known as progressive multifocal leukoencephalopathy (PML). JCV replicates in human glial progenitor cells and astrocytes, which undergo viral T-antigen-triggered mitosis, enabling viral replication. The authors were able to demonstrate that dividing [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-208665","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=208665"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208665\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=208665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=208665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=208665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}