{"id":208647,"date":"2025-03-13T23:12:23","date_gmt":"2025-03-14T04:12:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/cellular-rejuvenation-protects-neurons-from-inflammation-mediated-cell-death"},"modified":"2025-03-13T23:12:23","modified_gmt":"2025-03-14T04:12:23","slug":"cellular-rejuvenation-protects-neurons-from-inflammation-mediated-cell-death","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/cellular-rejuvenation-protects-neurons-from-inflammation-mediated-cell-death","title":{"rendered":"Cellular rejuvenation protects neurons from inflammation-mediated cell death"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cellular-rejuvenation-protects-neurons-from-inflammation-mediated-cell-death2.jpg\"><\/a><\/p>\n<p>Longevity snapshot 7 \u2014 cellular rejuvenation protects neurons.<\/p>\n<p><iframe loading=\"lazy\" title=\"Longevity Snapshot 7 - Cellular Rejuvenation Protects Neurons\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/IZ-o-JFbKDo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>Reviewing a Canadian study which uses cellular rejuvenation to protect retinal neurons in a mouse model of multiple sclerosis, preserving the vision of the mice.<\/p>\n<p>Study reviewed:<\/p>\n<p>In this manuscript, Drake et al. describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) like that of cortical neurons in patients with multiple sclerosis. Partial reprogramming with AAV2-Oct4-Sox2-Kl4 to rejuvenate the transcriptome results in improved RGC survival and visual acuity during EAE.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Longevity snapshot 7 \u2014 cellular rejuvenation protects neurons. Reviewing a Canadian study which uses cellular rejuvenation to protect retinal neurons in a mouse model of multiple sclerosis, preserving the vision of the mice. Study reviewed: In this manuscript, Drake et al. describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) [\u2026]<\/p>\n","protected":false},"author":731,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-208647","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/731"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=208647"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208647\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=208647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=208647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=208647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}