{"id":208231,"date":"2025-03-10T01:14:14","date_gmt":"2025-03-10T06:14:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/pck1-inhibits-cgas-sting-activation-by-consumption-of-gtp-to-promote-tumor-immune-evasion"},"modified":"2025-03-10T01:14:14","modified_gmt":"2025-03-10T06:14:14","slug":"pck1-inhibits-cgas-sting-activation-by-consumption-of-gtp-to-promote-tumor-immune-evasion","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/pck1-inhibits-cgas-sting-activation-by-consumption-of-gtp-to-promote-tumor-immune-evasion","title":{"rendered":"PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pck1-inhibits-cgas-sting-activation-by-consumption-of-gtp-to-promote-tumor-immune-evasion.gif\"><\/a><\/p>\n<p>New study from Wenxing Qin, Yuran Duan, Zhiqiang Hu, Yueru Hou, Daqian Xu and colleagues (Zhejiang University School of Medicine) unveils a novel mechanism by which the metabolic enzyme PCK1 hinders cGAS-STING activation by competitively consuming GTP, consequently fostering tumor immune evasion.<\/p>\n<hr>\n<p>This study unveils a novel mechanism by which the metabolic enzyme PCK1 hinders cGAS-STING activation by competitively consuming GTP, consequently fosterin.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New study from Wenxing Qin, Yuran Duan, Zhiqiang Hu, Yueru Hou, Daqian Xu and colleagues (Zhejiang University School of Medicine) unveils a novel mechanism by which the metabolic enzyme PCK1 hinders cGAS-STING activation by competitively consuming GTP, consequently fostering tumor immune evasion. This study unveils a novel mechanism by which the metabolic enzyme PCK1 hinders [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-208231","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=208231"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/208231\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=208231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=208231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=208231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}