{"id":207750,"date":"2025-03-04T03:24:08","date_gmt":"2025-03-04T09:24:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/brain-changes-from-early-life-stress-may-be-reversible"},"modified":"2025-03-04T03:24:08","modified_gmt":"2025-03-04T09:24:08","slug":"brain-changes-from-early-life-stress-may-be-reversible","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/brain-changes-from-early-life-stress-may-be-reversible","title":{"rendered":"Brain Changes From Early-Life Stress May Be Reversible"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-changes-from-early-life-stress-may-be-reversible.jpg\"><\/a><\/p>\n<p><strong>Summary: <\/strong>A new study reveals how prenatal infections followed by early-life stress\u2014known as \u201ctwo-hit stress\u201d\u2014can lead to brain dysfunction and psychiatric-like behaviors. Researchers found that affected mice showed abnormal cerebellar activity, increased microglial turnover, and impaired brain-wide connectivity.<\/p>\n<p>Notably, microglia replacement therapy successfully reversed these effects, offering a potential new approach for mental health treatments. The findings suggest that sex differences may influence stress resilience, highlighting the need for personalized treatments for psychiatric and neurodegenerative disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A new study reveals how prenatal infections followed by early-life stress\u2014known as \u201ctwo-hit stress\u201d\u2014can lead to brain dysfunction and psychiatric-like behaviors. Researchers found that affected mice showed abnormal cerebellar activity, increased microglial turnover, and impaired brain-wide connectivity. Notably, microglia replacement therapy successfully reversed these effects, offering a potential new approach for mental health treatments. [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47,1901],"tags":[],"class_list":["post-207750","post","type-post","status-publish","format-standard","hentry","category-neuroscience","category-sex"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/207750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=207750"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/207750\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=207750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=207750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=207750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}