{"id":207640,"date":"2025-03-02T20:06:41","date_gmt":"2025-03-03T02:06:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/03\/engineered-commensals-for-targeted-nose-to-brain-drug-delivery"},"modified":"2025-03-02T20:06:41","modified_gmt":"2025-03-03T02:06:41","slug":"engineered-commensals-for-targeted-nose-to-brain-drug-delivery","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/03\/engineered-commensals-for-targeted-nose-to-brain-drug-delivery","title":{"rendered":"Engineered commensals for targeted nose-to-brain drug delivery"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineered-commensals-for-targeted-nose-to-brain-drug-delivery2.jpg\"><\/a><\/p>\n<p>Shen et al. investigate the use of <i><i>Lactobacillus<\/i> plantarum<\/i>, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of <i>L. plantarum<\/i> alleviates obesity-related symptoms in a mouse model.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-207640","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/207640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=207640"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/207640\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=207640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=207640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=207640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}