{"id":207064,"date":"2025-02-23T18:03:17","date_gmt":"2025-02-24T00:03:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/mountain-air-in-a-pill-scientists-develop-drug-that-extends-life-and-reverses-brain-damage"},"modified":"2025-02-23T18:03:17","modified_gmt":"2025-02-24T00:03:17","slug":"mountain-air-in-a-pill-scientists-develop-drug-that-extends-life-and-reverses-brain-damage","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/mountain-air-in-a-pill-scientists-develop-drug-that-extends-life-and-reverses-brain-damage","title":{"rendered":"Mountain Air in a Pill? Scientists Develop Drug That Extends Life and Reverses Brain Damage"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mountain-air-in-a-pill-scientists-develop-drug-that-extends-life-and-reverses-brain-damage.jpg\"><\/a><\/p>\n<p><strong>Gladstone researchers create a drug that replicates the cellular effects of low-oxygen therapy to treat inherited mitochondrial diseases.<\/strong><\/p>\n<p>For most people, living at high altitudes\u2014where oxygen levels are lower than at sea level\u2014can offer health benefits, such as reduced rates of heart disease and improved endurance. However, for individuals with inherited mitochondrial diseases, who often do not survive beyond childhood, low-oxygen environments like those at high elevations could be life-saving, potentially prolonging their lifespan and alleviating symptoms.<\/p>\n<p>Now, researchers at <a href=\"https:\/\/scitechdaily.com\/tag\/gladstone-institutes\/\">Gladstone Institutes<\/a> have developed a drug that replicates the effects of low-oxygen exposure. In mice with Leigh Syndrome\u2014the most common childhood mitochondrial disease\u2014the drug, called HypoxyStat, extended lifespan more than threefold and reversed brain damage and muscle weakness, even when administered in the disease\u2019s late stages.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gladstone researchers create a drug that replicates the cellular effects of low-oxygen therapy to treat inherited mitochondrial diseases. For most people, living at high altitudes\u2014where oxygen levels are lower than at sea level\u2014can offer health benefits, such as reduced rates of heart disease and improved endurance. However, for individuals with inherited mitochondrial diseases, who often [\u2026]<\/p>\n","protected":false},"author":621,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-207064","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/207064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/621"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=207064"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/207064\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=207064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=207064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=207064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}