{"id":206958,"date":"2025-02-21T17:13:15","date_gmt":"2025-02-21T23:13:15","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/rna-neoantigen-vaccines-prime-long-lived-cd8-t-cells-in-pancreatic-cancer"},"modified":"2025-02-21T17:13:15","modified_gmt":"2025-02-21T23:13:15","slug":"rna-neoantigen-vaccines-prime-long-lived-cd8-t-cells-in-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/rna-neoantigen-vaccines-prime-long-lived-cd8-t-cells-in-pancreatic-cancer","title":{"rendered":"RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/rna-neoantigen-vaccines-prime-long-lived-cd8-t-cells-in-pancreatic-cancer.jpg\"><\/a><\/p>\n<p>In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.<\/p>\n","protected":false},"author":692,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-206958","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206958","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/692"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=206958"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206958\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=206958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=206958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=206958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}