{"id":206886,"date":"2025-02-21T02:04:05","date_gmt":"2025-02-21T08:04:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/a-mortality-timer-based-on-nucleolar-size-triggers-nucleolar-integrity-loss-and-catastrophic-genomic-instability"},"modified":"2025-02-21T02:04:05","modified_gmt":"2025-02-21T08:04:05","slug":"a-mortality-timer-based-on-nucleolar-size-triggers-nucleolar-integrity-loss-and-catastrophic-genomic-instability","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/a-mortality-timer-based-on-nucleolar-size-triggers-nucleolar-integrity-loss-and-catastrophic-genomic-instability","title":{"rendered":"A mortality timer based on nucleolar size triggers nucleolar integrity loss and catastrophic genomic instability"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-mortality-timer-based-on-nucleolar-size-triggers-nucleolar-integrity-loss-and-catastrophic-genomic-instability.jpg\"><\/a><\/p>\n<p>Gutierrez and Tyler investigate the limits of replicative lifespan in yeast. The authors show that nucleolar expansion during aging is a mortality timer. Enlargement of nucleoli beyond a defined size alters their biophysical properties; normally excluded DNA repair protein enter, causing aberrant rDNA recombination, genome instability and death.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gutierrez and Tyler investigate the limits of replicative lifespan in yeast. The authors show that nucleolar expansion during aging is a mortality timer. Enlargement of nucleoli beyond a defined size alters their biophysical properties; normally excluded DNA repair protein enter, causing aberrant rDNA recombination, genome instability and death.<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-206886","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=206886"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206886\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=206886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=206886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=206886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}