{"id":206678,"date":"2025-02-18T09:16:50","date_gmt":"2025-02-18T15:16:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/gold-nanodots-can-help-boost-cancer-cell-response-to-ultrasound-treatment"},"modified":"2025-02-18T09:16:50","modified_gmt":"2025-02-18T15:16:50","slug":"gold-nanodots-can-help-boost-cancer-cell-response-to-ultrasound-treatment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/gold-nanodots-can-help-boost-cancer-cell-response-to-ultrasound-treatment","title":{"rendered":"Gold nanodots can help boost cancer cell response to ultrasound treatment"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gold-nanodots-can-help-boost-cancer-cell-response-to-ultrasound-treatment2.jpg\"><\/a><\/p>\n<p>Cells have surface receptors called integrins that bind to repetitive domains present on the extracellular matrix (ECM) surrounding the cells, allowing them to grow and spread. A new study from the Department of Bioengineering (BE), Indian Institute of Science (IISc) and collaborators shows that tweaking the spacing between these binding domains on the ECM can boost the efficiency of ultrasound treatment applied to kill cancer cells.<\/p>\n<p>\u201cIn a normal tissue, the spacing on the ECM is around 50\u201370 nanometers (nm), but in the <a href=\"https:\/\/phys.org\/tags\/tumor+microenvironment\/\" rel=\"tag\" class=\"\">tumor microenvironment<\/a>, severe choking occurs due to excessive ECM secretion, which may reduce the binding spacing to below 50 nm,\u201d explains Ajay Tijore, Assistant Professor in BE and corresponding author of a related study <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.4c05858\" target=\"_blank\">published<\/a> in <i>Nano Letters<\/i>. \u201cWe found more <a href=\"https:\/\/phys.org\/tags\/cancer+cells\/\" rel=\"tag\" class=\"\">cancer cells<\/a> being killed when the binding spacing is increased to around 50\u201370 nm.\u201d<\/p>\n<p>Low-frequency ultrasound waves (39 kHz) can disrupt the <a href=\"https:\/\/phys.org\/tags\/cell+membrane\/\" rel=\"tag\" class=\"\">cell membrane<\/a> and trigger cell death in cancer cells. It is a relatively low-cost and non-invasive approach. Unlike normal cells, cancer cells do not have repair mechanisms that help them withstand the <a href=\"https:\/\/phys.org\/tags\/mechanical+forces\/\" rel=\"tag\" class=\"\">mechanical forces<\/a> exerted by ultrasound waves.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cells have surface receptors called integrins that bind to repetitive domains present on the extracellular matrix (ECM) surrounding the cells, allowing them to grow and spread. A new study from the Department of Bioengineering (BE), Indian Institute of Science (IISc) and collaborators shows that tweaking the spacing between these binding domains on the ECM can [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11],"tags":[],"class_list":["post-206678","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=206678"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206678\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=206678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=206678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=206678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}