{"id":206045,"date":"2025-02-10T10:12:08","date_gmt":"2025-02-10T16:12:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/cerebrospinal-biomarker-test-can-detect-alzheimers-pathology-earlier-study-shows"},"modified":"2025-02-10T10:12:08","modified_gmt":"2025-02-10T16:12:08","slug":"cerebrospinal-biomarker-test-can-detect-alzheimers-pathology-earlier-study-shows","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/cerebrospinal-biomarker-test-can-detect-alzheimers-pathology-earlier-study-shows","title":{"rendered":"Cerebrospinal biomarker test can detect Alzheimer\u2019s pathology earlier, study shows"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cerebrospinal-biomarker-test-can-detect-alzheimers-pathology-earlier-study-shows2.jpg\"><\/a><\/p>\n<p>Years before tau tangles show up in brain scans of patients with Alzheimer\u2019s disease, a biomarker test developed at the University of Pittsburgh School of Medicine can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal fluid and potentially blood, new research published today in <i>Nature Medicine<\/i> suggests.<\/p>\n<p>The <a href=\"https:\/\/medicalxpress.com\/tags\/cerebrospinal+fluid\/\" rel=\"tag\" class=\"\">cerebrospinal fluid<\/a> biomarker test correlates with the severity of cognitive decline, independent of other factors, including brain amyloid deposition, thereby opening doors for early-stage disease diagnosis and intervention.<\/p>\n<p>Since amyloid-beta pathology often precedes tau abnormalities in Alzheimer\u2019s disease, most biomarker efforts have focused on early detection of amyloid-beta changes. However, the clumping of tau protein into well-ordered structures referred to by pathologists as \u201c<a href=\"https:\/\/medicalxpress.com\/tags\/neurofibrillary+tangles\/\" rel=\"tag\" class=\"\">neurofibrillary tangles<\/a>\u201d is a more defining event for Alzheimer\u2019s disease as it is more strongly associated with the cognitive changes seen in affected people.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Years before tau tangles show up in brain scans of patients with Alzheimer\u2019s disease, a biomarker test developed at the University of Pittsburgh School of Medicine can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal fluid and potentially blood, new research published today in Nature [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-206045","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=206045"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/206045\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=206045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=206045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=206045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}