{"id":205985,"date":"2025-02-09T20:00:23","date_gmt":"2025-02-10T02:00:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/r-loops-acted-on-by-rnase-h1-influence-dna-replication-timing-and-genome-stability-in-leishmania"},"modified":"2025-02-09T20:00:23","modified_gmt":"2025-02-10T02:00:23","slug":"r-loops-acted-on-by-rnase-h1-influence-dna-replication-timing-and-genome-stability-in-leishmania","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/r-loops-acted-on-by-rnase-h1-influence-dna-replication-timing-and-genome-stability-in-leishmania","title":{"rendered":"R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/r-loops-acted-on-by-rnase-h1-influence-dna-replication-timing-and-genome-stability-in-leishmania.jpg\"><\/a><\/p>\n<p>All genomes are replicated in a temporal order, though the determinants of such timing are poorly characterized. Here, the authors show that the unusual chromosome size-dependent DNA replication timing in <i>Leishmania<\/i> is influenced by RNA-DNA hybrids that are recognised by the endonuclease RNase H1.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>All genomes are replicated in a temporal order, though the determinants of such timing are poorly characterized. Here, the authors show that the unusual chromosome size-dependent DNA replication timing in Leishmania is influenced by RNA-DNA hybrids that are recognised by the endonuclease RNase H1.<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-205985","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205985"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205985\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}