{"id":205860,"date":"2025-02-07T17:16:04","date_gmt":"2025-02-07T23:16:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/outside-in-signaling-shows-a-route-into-cancer-cells"},"modified":"2025-02-07T17:16:04","modified_gmt":"2025-02-07T23:16:04","slug":"outside-in-signaling-shows-a-route-into-cancer-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/outside-in-signaling-shows-a-route-into-cancer-cells","title":{"rendered":"Outside-In Signaling Shows a Route Into Cancer Cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/outside-in-signaling-shows-a-route-into-cancer-cells.jpg\"><\/a><\/p>\n<p>A new study shows how an anticancer drug triggers an \u201coutside in\u201d signal that gets it sucked into a cancer cell. The work, published Jan. 29 in <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-56478-6\">Nature Communications<\/a>, reveals a new signaling mechanism that could be exploited for delivering other drugs.<\/p>\n<p>Many malignant cancers overexpress a protein called P-cadherin, which is embedded in the cell membrane. Because cancer cells have a lot of P-cadherin sticking out of their surface, the protein has been targeted for drug development.<\/p>\n<p>Monoclonal antibodies against P-cadherin can carry a drug payload to the cancer cells. It has not been clear, though, exactly how the antibodies attach to P-cadherin or how they get inside the cancer cell once attached.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study shows how an anticancer drug triggers an \u201coutside in\u201d signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism that could be exploited for delivering other drugs. Many malignant cancers overexpress a protein called P-cadherin, which is embedded in the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-205860","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205860"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205860\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}