{"id":205822,"date":"2025-02-07T12:09:13","date_gmt":"2025-02-07T18:09:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/xenon-gas-could-protect-against-alzheimers-disease-mouse-study"},"modified":"2025-02-07T12:09:13","modified_gmt":"2025-02-07T18:09:13","slug":"xenon-gas-could-protect-against-alzheimers-disease-mouse-study","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/xenon-gas-could-protect-against-alzheimers-disease-mouse-study","title":{"rendered":"Xenon Gas could Protect Against Alzheimer\u2019s Disease: Mouse study"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/xenon-gas-could-protect-against-alzheimers-disease-mouse-study.jpg\"><\/a><\/p>\n<p>Xenon gas inhalation reduced neurodegeneration and boosted protection in preclinical models of Alzheimer\u2019s disease. Most treatments being pursued today to protect against Alzheimer\u2019s disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research from Mass General Brigham and Washington University School of Medicine in St. Louis points to a novel \u2014 and noble \u2014 approach: using Xenon gas. The study found that Xenon gas inhalation suppressed neuroinflammation, reduced brain atrophy, and increased protective neuronal states in mouse models of Alzheimer\u2019s disease. Results are published in Science Translational Medicine, and a phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.<\/p>\n<p>\u201cIt is a very novel discovery showing that simply inhaling an inert gas can have such a profound neuroprotective effect,\u201d said senior and co-corresponding author Oleg Butovsky, PhD, of the Ann Romney Center for Neurologic Diseases at Brigham and Women\u2019s Hospital (BWH), a founding member of the Mass General Brigham healthcare system. \u201cOne of the main limitations in the field of Alzheimer\u2019s disease research and treatment is that it is extremely difficult to design medications that can pass the blood-brain barrier \u2014 but Xenon gas does. We look forward to seeing this novel approach tested in humans.\u201d<\/p>\n<p>\u201cIt is exciting that in both animal models that model different aspects of Alzheimer\u2019s disease, amyloid pathology in one model and tau pathology in another model, that Xenon had protective effects in both situations,\u201d said senior and co-corresponding author David M. Holtzman, MD, from Washington University School of Medicine in St. Louis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xenon gas inhalation reduced neurodegeneration and boosted protection in preclinical models of Alzheimer\u2019s disease. Most treatments being pursued today to protect against Alzheimer\u2019s disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research from Mass General Brigham and Washington University School of Medicine in St. Louis points to a [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-205822","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205822"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205822\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}